タイトル | Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. |
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ジャーナル・号・ページ | Mol. Cell, Vol. 82, Page 4080-4098.e12, Year 2022 |
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掲載日 | 2021年2月25日 (構造データの登録日) |
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著者 | Song, L. / Yao, X. / Li, H. / Peng, B. / Boka, A.P. / Liu, Y. / Chen, G. / Liu, Z. / Mathias, K.M. / Xia, L. ...Song, L. / Yao, X. / Li, H. / Peng, B. / Boka, A.P. / Liu, Y. / Chen, G. / Liu, Z. / Mathias, K.M. / Xia, L. / Li, Q. / Mir, M. / Li, Y. / Wan, L. |
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リンク | Mol. Cell / PubMed:36272410 |
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手法 | X線回折 |
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解像度 | 1.91 - 2.9 Å |
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構造データ | PDB-7e74: Crystal structure of ENL YEATS domain T3 mutant in complex with histone H3 acetylation at K27 手法: X-RAY DIFFRACTION / 解像度: 2.9 Å PDB-7x88: Crystal structure of ENL YEATS domain T2 mutant in complex with histone H3 acetylation at K27 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-7x8b: Crystal structure of ENL T1 mutant YEATS domain in complex with histone H3 acetylation at K27 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-7x8f: Crystal structure of ENL T4 mutant YEATS domain in complex with histone H3 acetylation at K27 手法: X-RAY DIFFRACTION / 解像度: 2.44 Å PDB-7x8g: Crystal structure of ENL T1(H116P) mutant YEATS domain in complex with histone H3 acetylation at K27 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å |
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化合物 | |
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由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
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キーワード | TRANSCRIPTION (転写 (生物学)) / YEATS domain / Complex / histone (ヒストン) / GENE REGULATION (遺伝子発現の調節) |
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