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TitleThermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.
Journal, issue, pagesAntiviral Res., Vol. 208, Page 105449-105449, Year 2022
Publish dateApr 29, 2022 (structure data deposition date)
AuthorsRadilova, K. / Zima, V. / Kral, M. / Machara, A. / Majer, P. / Hodek, J. / Weber, J. / Brynda, J. / Strmen, T. / Konvalinka, J. / Kozisek, M.
External linksAntiviral Res. / PubMed:36265804
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-7zpy:
Influenza polymerase A C-terminal domain of PA subunit with optimized small peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MOE:
METHOXY-ETHOXYL

ChemComp-HOH:
WATER

Source
  • influenza a virus (a/california/07/2009(h1n1))
  • synthetic construct (others)
KeywordsVIRAL PROTEIN / antiviral peptides / Influenza A polymerase / protein-protein interaction

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