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Structure paper

TitleFusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3.
Journal, issue, pagesAcs Chem. Biol., Vol. 17, Page 2972-2978, Year 2022
Publish dateJan 19, 2021 (structure data deposition date)
AuthorsBrink, H.J. / van Senten, J.R. / De Vries-van Leeuwen, I.J. / da Costa Pereira, D. / Piersma, S.R. / Jimenez, C.R. / Centorrino, F. / Ottmann, C. / Siderius, M. / Smit, M.J. / de Boer, A.H.
External linksAcs Chem. Biol. / PubMed:36255265
MethodsX-ray diffraction
Resolution1.8 - 2 Å
Structure data

PDB-7bm9:
Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7bmc:
Crystal structure of 14-3-3 sigma in complex with CIP2ApS904 peptide and stabilizing Fusicoccin A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-FSC:
FUSICOCCIN

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / protein-peptide complex

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