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Structure paper

TitleADAR activation by inducing a syn conformation at guanosine adjacent to an editing site.
Journal, issue, pagesNucleic Acids Res., Vol. 50, Page 10857-10868, Year 2022
Publish dateAug 9, 2022 (structure data deposition date)
AuthorsDoherty, E.E. / Karki, A. / Wilcox, X.E. / Mendoza, H.G. / Manjunath, A. / Matos, V.J. / Fisher, A.J. / Beal, P.A.
External linksNucleic Acids Res. / PubMed:36243986
MethodsX-ray diffraction
Resolution2.7 - 2.8 Å
Structure data

PDB-8e0f:
Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-8e4x:
Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN/RNA / Protein-RNA complex / RNA editing / RNA BINDING PROTEIN / RNA BINDING PROTEIN-RNA complex

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