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| Title | Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry. |
|---|---|
| Journal, issue, pages | Nat Commun, Vol. 13, Page 5884-5884, Year 2022 |
| Publish date | Sep 8, 2021 (structure data deposition date) |
 Authors | Dixon, T. / MacPherson, D. / Mostofian, B. / Dauzhenka, T. / Lotz, S. / McGee, D. / Shechter, S. / Shrestha, U.R. / Wiewiora, R. / McDargh, Z.A. ...Dixon, T. / MacPherson, D. / Mostofian, B. / Dauzhenka, T. / Lotz, S. / McGee, D. / Shechter, S. / Shrestha, U.R. / Wiewiora, R. / McDargh, Z.A. / Pei, F. / Pal, R. / Ribeiro, J.V. / Wilkerson, T. / Sachdeva, V. / Gao, N. / Jain, S. / Sparks, S. / Li, Y. / Vinitsky, A. / Zhang, X. / Razavi, A.M. / Kolossvary, I. / Imbriglio, J. / Evdokimov, A. / Bergeron, L. / Zhou, W. / Adhikari, J. / Ruprecht, B. / Dickson, A. / Xu, H. / Sherman, W. / Izaguirre, J.A. |
 External links | Nat Commun / PubMed:36202813 |
| Methods | X-ray diffraction |
| Resolution | 2.25 Å |
| Structure data |  PDB-7s4e: |
| Chemicals |  ChemComp-EDO:  ChemComp-NA:  ChemComp-PEG:  ChemComp-87A:  ChemComp-HOH: |
| Source |
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 Keywords | GENE REGULATION / Complex / PROTAC / Degradation / Assembly |
homo sapiens (human)