タイトル | A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability. |
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ジャーナル・号・ページ | Cancer Discov, Vol. 13, Page 56-69, Year 2023 |
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掲載日 | 2022年6月15日 (構造データの登録日) |
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著者 | Guiley, K.Z. / Shokat, K.M. |
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リンク | Cancer Discov / PubMed:36197521 |
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手法 | X線回折 |
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解像度 | 1.60000908706 - 2.4 Å |
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構造データ | PDB-8dc4: Crystal structure of p53 Y220C covalently bound to carbazole KG3 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-8dc6: Crystal structure of p53 Y220C covalently bound to indole KG6 手法: X-RAY DIFFRACTION / 解像度: 1.60000908706 Å PDB-8dc7: Crystal structure of p53 Y220C covalently bound to indole KG10 手法: X-RAY DIFFRACTION / 解像度: 1.98700696061 Å PDB-8dc8: Crystal structure of p53 Y220C covalently bound to azaindole KG13 手法: X-RAY DIFFRACTION / 解像度: 1.72009735908 Å |
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化合物 | ChemComp-R3R: 9-propanoyl-9H-carbazole-3-carbaldehyde, bound form
ChemComp-R4F: 1-(2-methylprop-2-enoyl)-1H-indole-3-carbaldehyde, bound form
ChemComp-R4R: 4-[4-(4-methylpiperazin-1-yl)phenyl]-1-(2-methylprop-2-enoyl)-1H-indole-3-carbaldehyde, bound form
ChemComp-R50: 2-methyl-1-[(4P)-3-methyl-4-(2-methyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl]prop-2-en-1-one, bound form
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由来 | homo sapiens (ヒト)
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キーワード | CELL CYCLE / TP53 / tumor suppressor / p53 |
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