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-Structure paper
Title | Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 243, Page 114778-114778, Year 2022 |
Publish date | Jan 10, 2022 (structure data deposition date) |
Authors | Napolitano, V. / Mroz, P. / Marciniak, M. / Kalel, V.C. / Softley, C.A. / Janna Olmos, J.D. / Tippler, B.G. / Schorpp, K. / Rioton, S. / Frohlich, T. ...Napolitano, V. / Mroz, P. / Marciniak, M. / Kalel, V.C. / Softley, C.A. / Janna Olmos, J.D. / Tippler, B.G. / Schorpp, K. / Rioton, S. / Frohlich, T. / Plettenburg, O. / Hadian, K. / Erdmann, R. / Sattler, M. / Popowicz, G.M. / Dawidowski, M. / Dubin, G. |
External links | Eur. J. Med. Chem. / PubMed:36194937 |
Methods | X-ray diffraction |
Resolution | 2.18 Å |
Structure data | PDB-7qrc: |
Chemicals | ChemComp-GOL: ChemComp-ET7: ChemComp-HOH: |
Source |
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Keywords | SIGNALING PROTEIN / Structure-based drug design / Inhibitor / Trypanosomiasis / Complex / PEX5-PEX14 PPI |