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Title | Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 13240-13252, Year 2022 |
Publish date | Sep 28, 2021 (structure data deposition date) |
![]() | Zhang, W. / Lun, S. / Wang, S.S. / Cai, Y.P. / Yang, F. / Tang, J. / Bishai, W.R. / Yu, L.F. |
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Methods | X-ray diffraction |
Resolution | 1.94 Å |
Structure data | ![]() PDB-7vjt: |
Chemicals | ![]() ChemComp-7IJ: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Tuberculosis / Mycobacterium tuberculosis / ANTIBIOTIC |