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Title | Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 12701-12724, Year 2022 |
Publish date | Mar 11, 2022 (structure data deposition date) |
![]() | Sainas, S. / Giorgis, M. / Circosta, P. / Poli, G. / Alberti, M. / Passoni, A. / Gaidano, V. / Pippione, A.C. / Vitale, N. / Bonanni, D. ...Sainas, S. / Giorgis, M. / Circosta, P. / Poli, G. / Alberti, M. / Passoni, A. / Gaidano, V. / Pippione, A.C. / Vitale, N. / Bonanni, D. / Rolando, B. / Cignetti, A. / Ramondetti, C. / Lanno, A. / Ferraris, D.M. / Canepa, B. / Buccinna, B. / Piccinini, M. / Rizzi, M. / Saglio, G. / Al-Karadaghi, S. / Boschi, D. / Miggiano, R. / Tuccinardi, T. / Lolli, M.L. |
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Methods | X-ray diffraction |
Resolution | 1.85 Å |
Structure data | ![]() PDB-7z6c: |
Chemicals | ![]() ChemComp-FMN: ![]() ChemComp-ORO: ![]() ChemComp-IEQ: ![]() ChemComp-P6G: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / Dihydroorotate Dehydrogenase / inhibitor / complex / acute myeloid leukaemia. |