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Structure paper

TitleStructure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Journal, issue, pagesNat Commun, Vol. 13, Page 5603-5603, Year 2022
Publish dateMay 19, 2022 (structure data deposition date)
AuthorsKo, K.T. / Lennartz, F. / Mekhaiel, D. / Guloglu, B. / Marini, A. / Deuker, D.J. / Long, C.A. / Jore, M.M. / Miura, K. / Biswas, S. / Higgins, M.K.
External linksNat Commun / PubMed:36153317
MethodsX-ray diffraction
Resolution1.9 - 4.2 Å
Structure data

PDB-7zwf:
Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3
Method: X-RAY DIFFRACTION / Resolution: 2.132 Å

PDB-7zwi:
Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7zwm:
Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3
Method: X-RAY DIFFRACTION / Resolution: 3.69 Å

PDB-7zxf:
Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1
Method: X-RAY DIFFRACTION / Resolution: 3.72 Å

PDB-7zxg:
Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8
Method: X-RAY DIFFRACTION / Resolution: 4.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
  • mus musculus (house mouse)
  • rattus norvegicus (Norway rat)
KeywordsCELL ADHESION / Pfs48/45 / malaria / transmission-blocking / Plasmodium falciparum / gamete / antibody

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