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TitleInsight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors.
Journal, issue, pagesNat Commun, Vol. 13, Page 5519-5519, Year 2022
Publish dateDec 15, 2020 (structure data deposition date)
AuthorsLamers, C. / Xue, X. / Smiesko, M. / van Son, H. / Wagner, B. / Berger, N. / Sfyroera, G. / Gros, P. / Lambris, J.D. / Ricklin, D.
External linksNat Commun / PubMed:36127336
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-7bag:
C3b in complex with CP40
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-ACM:
ACETAMIDE

ChemComp-NH2:
AMINO GROUP

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Complement system / C3b / C3 convertase / Inhibitor

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