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TitleDesign of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.
Journal, issue, pagesSci Adv, Vol. 8, Page eabq8276-eabq8276, Year 2022
Publish dateJun 16, 2022 (structure data deposition date)
AuthorsDickey, T.H. / Tang, W.K. / Butler, B. / Ouahes, T. / Orr-Gonzalez, S. / Salinas, N.D. / Lambert, L.E. / Tolia, N.H.
External linksSci Adv / PubMed:36103542
MethodsX-ray diffraction
Resolution2 - 2.6 Å
Structure data

PDB-8dcc:
SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 3 Bound to P2B-2F6 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8dce:
SARS-CoV-2 Receptor-Binding Domain SPEEDesign Immunogen 1 Bound to C144 scFv
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Immunogen / antigen / design / vaccine / VIRAL PROTEIN-IMMUNE SYSTEM complex

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