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TitleTargeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 75, Page 128950-128950, Year 2022
Publish dateMar 4, 2022 (structure data deposition date)
AuthorsKiyeleko, S. / Hocine, S. / Mautino, G. / Kuenemann, M. / Nawrotek, A. / Miallau, L. / Vuillard, L.M. / Mirguet, O. / Kotschy, A. / Hanessian, S.
External linksBioorg. Med. Chem. Lett. / PubMed:36030002
MethodsX-ray diffraction
Resolution1.644 Å
Structure data

PDB-7z4v:
Structure of Serine-Threonine kinase STK25 in complex with compound
Method: X-RAY DIFFRACTION / Resolution: 1.644 Å

Chemicals

ChemComp-IB5:
~{N}-(5-~{tert}-butyl-1~{H}-pyrazol-3-yl)-4-pyrrolidin-1-ylsulfonyl-benzamide

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / tumor suppressor / phosphorylation / YAP/TAZ / kinase

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