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TitleInsight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1.
Journal, issue, pagesBiochemistry, Vol. 61, Page 1723-1734, Year 2022
Publish dateMar 30, 2022 (structure data deposition date)
AuthorsWang, J. / Sachpatzidis, A. / Christian, T.D. / Lomakin, I.B. / Garen, A. / Konigsberg, W.H.
External linksBiochemistry / PubMed:35998361
MethodsX-ray diffraction
Resolution2.7 - 3.5 Å
Structure data

PDB-7uj1:
Crystal structure of PSF-RNA complex
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

PDB-7uk1:
Complex Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) with Murine Virus-like 30S Transcript-1 (VS30-1) Reveals Cooperative Binding of RNA
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsRNA BINDING PROTEIN/RNA / RNA-recognition motif / DNA binding / transcription regulation / polypyrimidine binding / RNA BINDING PROTEIN-RNA complex / SPLICING / Polypyridimine-binding splicing factor / 5'-polyuridine negative-sense (5'-PUN) template / RNA-dependent DNA-binding regulation / DNA-binding domain (DBD) / RNA-binding motif (RRM) / VL30-1 / Allostery / Cooperativity

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