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Structure paper

TitleEvybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis.
Journal, issue, pagesNat. Chem. Biol., Vol. 18, Page 1236-1244, Year 2022
Publish dateMar 25, 2022 (structure data deposition date)
AuthorsImai, Y. / Hauk, G. / Quigley, J. / Liang, L. / Son, S. / Ghiglieri, M. / Gates, M.F. / Morrissette, M. / Shahsavari, N. / Niles, S. ...Imai, Y. / Hauk, G. / Quigley, J. / Liang, L. / Son, S. / Ghiglieri, M. / Gates, M.F. / Morrissette, M. / Shahsavari, N. / Niles, S. / Baldisseri, D. / Honrao, C. / Ma, X. / Guo, J.J. / Berger, J.M. / Lewis, K.
External linksNat. Chem. Biol. / PubMed:35996001
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-7ugw:
M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MG:
Unknown entry

Source
  • mycobacterium tuberculosis h37rv (bacteria)
  • photorhabdus noenieputensis (bacteria)
  • synthetic construct (others)
KeywordsISOMERASE/ANTIBIOTIC/DNA / Topoisomerase / inhibitor / natural product / ISOMERASE-ANTIBIOTIC-DNA complex

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