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TitleDiscovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 74, Page 128929-128929, Year 2022
Publish dateJan 21, 2022 (structure data deposition date)
AuthorsCaldwell, T.M. / Kaufman, M.D. / Wise, S.C. / Mi Ahn, Y. / Hood, M.M. / Lu, W.P. / Patt, W.C. / Samarakoon, T. / Vogeti, L. / Vogeti, S. ...Caldwell, T.M. / Kaufman, M.D. / Wise, S.C. / Mi Ahn, Y. / Hood, M.M. / Lu, W.P. / Patt, W.C. / Samarakoon, T. / Vogeti, L. / Vogeti, S. / Yates, K.M. / Bulfer, S.L. / Le Bourdonnec, B. / Smith, B.D. / Flynn, D.L.
External linksBioorg. Med. Chem. Lett. / PubMed:35961461
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-7tnh:
Crystal structure of CSF1R kinase domain in complex with DP-6233
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-I9W:
2,2-dimethyl-N-[(6-methyl-5-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / human CSR1R kinase / cancer

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