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TitleDiscovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 10882-10897, Year 2022
Publish dateApr 5, 2022 (structure data deposition date)
AuthorsIijima, D. / Sugama, H. / Takahashi, Y. / Hirai, M. / Togashi, Y. / Xie, J. / Shen, J. / Ke, Y. / Akatsuka, H. / Kawaguchi, T. ...Iijima, D. / Sugama, H. / Takahashi, Y. / Hirai, M. / Togashi, Y. / Xie, J. / Shen, J. / Ke, Y. / Akatsuka, H. / Kawaguchi, T. / Takedomi, K. / Kashima, A. / Nishio, M. / Inui, Y. / Yoneda, H. / Xia, G. / Iijima, T.
External linksJ. Med. Chem. / PubMed:35939295
MethodsX-ray diffraction
Resolution2.65 Å
Structure data

PDB-7xgp:
Human renin in complex with compound3
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose


ChemComp, No image

ChemComp-UNL:
Unknown ligand

Source
  • homo sapiens (human)
KeywordsHYDROLASE/INHIBITOR / HYDROLASE-INHIBITOR COMPLEX

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