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Title | GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 11177-11186, Year 2022 |
Publish date | Dec 20, 2021 (structure data deposition date) |
Authors | Taylor, A.M. / Bailey, C. / Belmont, L.D. / Campbell, R. / Cantone, N. / Cote, A. / Crawford, T.D. / Cummings, R. / DeMent, K. / Duplessis, M. ...Taylor, A.M. / Bailey, C. / Belmont, L.D. / Campbell, R. / Cantone, N. / Cote, A. / Crawford, T.D. / Cummings, R. / DeMent, K. / Duplessis, M. / Flynn, M. / Good, A.C. / Huang, H.R. / Joshi, S. / Leblanc, Y. / Murray, J. / Nasveschuk, C.G. / Neiss, A. / Poy, F. / Romero, F.A. / Sandy, P. / Tang, Y. / Tsui, V. / Zawadzke, L. / Sims 3rd, R.J. / Audia, J.E. / Bellon, S.F. / Magnuson, S.R. / Albrecht, B.K. / Cochran, A.G. |
External links | J. Med. Chem. / PubMed:35930799 |
Methods | X-ray diffraction |
Resolution | 1.16 - 1.61 Å |
Structure data | PDB-7tab: PDB-7td9: |
Chemicals | ChemComp-GGU: ChemComp-HOH: ChemComp-GJN: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / bromodomain BRG1 SMARCA4 inhibitor / protein binding / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE |