+Search query
-Structure paper
Title | An anti-CTLA-4 heavy chain-only antibody with enhanced T reg depletion shows excellent preclinical efficacy and safety profile. |
---|---|
Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 119, Page e2200879119-e2200879119, Year 2022 |
Publish date | Jan 12, 2021 (structure data deposition date) |
Authors | Gan, X. / Shan, Q. / Li, H. / Janssens, R. / Shen, Y. / He, Y. / Chen, F. / van Haperen, R. / Drabek, D. / Li, J. ...Gan, X. / Shan, Q. / Li, H. / Janssens, R. / Shen, Y. / He, Y. / Chen, F. / van Haperen, R. / Drabek, D. / Li, J. / Zhang, Y. / Zhao, J. / Qin, B. / Jheng, M.J. / Chen, V. / Wang, J. / Rong, Y. / Grosveld, F. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:35925889 |
Methods | X-ray diffraction |
Resolution | 2.38 Å |
Structure data | PDB-7dv4: |
Chemicals | ChemComp-EDO: ChemComp-HOH: |
Source |
|
Keywords | IMMUNE SYSTEM / anti-tumor / VH domain / complex |