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-Structure paper
Title | Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. |
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Journal, issue, pages | Sci Transl Med, Vol. 14, Page eabn3231-eabn3231, Year 2022 |
Publish date | Oct 29, 2021 (structure data deposition date) |
![]() | Swale, C. / Bellini, V. / Bowler, M.W. / Flore, N. / Brenier-Pinchart, M.P. / Cannella, D. / Belmudes, L. / Mas, C. / Coute, Y. / Laurent, F. ...Swale, C. / Bellini, V. / Bowler, M.W. / Flore, N. / Brenier-Pinchart, M.P. / Cannella, D. / Belmudes, L. / Mas, C. / Coute, Y. / Laurent, F. / Scherf, A. / Bougdour, A. / Hakimi, M.A. |
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Methods | X-ray diffraction |
Resolution | 2.31 Å |
Structure data | ![]() PDB-7q4a: |
Chemicals | ![]() ChemComp-A9I: ![]() ChemComp-GOL: ![]() ChemComp-PEG: ![]() ChemComp-SCN: ![]() ChemComp-HOH: |
Source |
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![]() | SPLICING / Spliceosome / kinase inhibitor / splicing inhibition |