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| Title | Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling. |
|---|---|
| Journal, issue, pages | Nat Cancer, Vol. 3, Page 821-836, Year 2022 |
| Publish date | Aug 3, 2021 (structure data deposition date) |
 Authors | Wilding, B. / Scharn, D. / Bose, D. / Baum, A. / Santoro, V. / Chetta, P. / Schnitzer, R. / Botesteanu, D.A. / Reiser, C. / Kornigg, S. ...Wilding, B. / Scharn, D. / Bose, D. / Baum, A. / Santoro, V. / Chetta, P. / Schnitzer, R. / Botesteanu, D.A. / Reiser, C. / Kornigg, S. / Knesl, P. / Hormann, A. / Koferle, A. / Corcokovic, M. / Lieb, S. / Scholz, G. / Bruchhaus, J. / Spina, M. / Balla, J. / Peric-Simov, B. / Zimmer, J. / Mitzner, S. / Fett, T.N. / Beran, A. / Lamarre, L. / Gerstberger, T. / Gerlach, D. / Bauer, M. / Bergner, A. / Schlattl, A. / Bader, G. / Treu, M. / Engelhardt, H. / Zahn, S. / Fuchs, J.E. / Zuber, J. / Ettmayer, P. / Pearson, M. / Petronczki, M. / Kraut, N. / McConnell, D.B. / Solca, F. / Neumuller, R.A. |
 External links | Nat Cancer / PubMed:35883003 |
| Methods | X-ray diffraction |
| Resolution | 1.77 Å |
| Structure data |  PDB-7pcd: |
| Chemicals |  ChemComp-70I:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / HER2 / covalent Inhibitor |
homo sapiens (human)