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TitleStructural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut.
Journal, issue, pagesNat Commun, Vol. 13, Page 4324-4324, Year 2022
Publish dateFeb 15, 2022 (structure data deposition date)
AuthorsTaleb, V. / Liao, Q. / Narimatsu, Y. / Garcia-Garcia, A. / Companon, I. / Borges, R.J. / Gonzalez-Ramirez, A.M. / Corzana, F. / Clausen, H. / Rovira, C. / Hurtado-Guerrero, R.
External linksNat Commun / PubMed:35882872
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-7yx8:
Crystal structure of the AM0627 (E326A) inactive mutant in complex with PSGL-1-like bis-T glycopeptide and Zn2+
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • akkermansia muciniphila (bacteria)
  • synthetic construct (others)
KeywordsHYDROLASE / Glycoprotease / mucinase / T antigen / Tn antigen / AM0627

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