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Structure paper

TitleH 2 S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine.
Journal, issue, pagesCell. Mol. Life Sci., Vol. 79, Page 438-438, Year 2022
Publish dateDec 10, 2021 (structure data deposition date)
AuthorsPetrosino, M. / Zuhra, K. / Kopec, J. / Hutchin, A. / Szabo, C. / Majtan, T.
External linksCell. Mol. Life Sci. / PubMed:35864237
MethodsX-ray diffraction
Resolution2.691 Å
Structure data

PDB-7qgt:
Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA.
Method: X-RAY DIFFRACTION / Resolution: 2.691 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

ChemComp-IK2:
4'-DEOXY-4'-ACETYLYAMINO-PYRIDOXAL-5'-PHOSPHATE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / METHIONINE CYCLE / METABOLIC PATHWAY / SERINE METABOLISM

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