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TitleHelical remodeling augments 5-lipoxygenase activity in the synthesis of proinflammatory mediators.
Journal, issue, pagesJ. Biol. Chem., Vol. 298, Page 102282-102282, Year 2022
Publish dateFeb 1, 2022 (structure data deposition date)
AuthorsGallegos, E.M. / Reed, T.D. / Mathes, F.A. / Guevara, N.V. / Neau, D.B. / Huang, W. / Newcomer, M.E. / Gilbert, N.C.
External linksJ. Biol. Chem. / PubMed:35863431
MethodsX-ray diffraction
Resolution2.1 - 2.43 Å
Structure data

PDB-7ttj:
Stable-5-LOX elongated Ha2
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7ttl:
Stable-5-LOX elongated Ha2 (4 copies ASU)
Method: X-RAY DIFFRACTION / Resolution: 2.43 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / lipoxygenase / dioxygenase / membrane-binding

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