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-Structure paper
Title | Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 13, Page 1165-1171, Year 2022 |
Publish date | May 9, 2022 (structure data deposition date) |
![]() | Hill, M.D. / Fang, H. / Norris, D. / Delucca, G.V. / Huang, H. / DeBenedetto, M. / Quesnelle, C. / Schmitz, W.D. / Tokarski, J.S. / Sheriff, S. ...Hill, M.D. / Fang, H. / Norris, D. / Delucca, G.V. / Huang, H. / DeBenedetto, M. / Quesnelle, C. / Schmitz, W.D. / Tokarski, J.S. / Sheriff, S. / Yan, C. / Fanslau, C. / Haarhoff, Z. / Huang, C. / Kramer, M. / Madari, S. / Menard, K. / Monereau, L. / Morrison, J. / Raghavan, N. / Shields, E.E. / Simmermacher-Mayer, J. / Sinz, M. / Tye, C.K. / Westhouse, R. / Xie, C. / Zhang, H. / Zhang, L. / Zvyaga, T. / Lee, F. / Gavai, A.V. / Degnan, A.P. |
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Methods | X-ray diffraction |
Resolution | 1.685 Å |
Structure data | ![]() PDB-7uzn: |
Chemicals | ![]() ChemComp-PQF: ![]() ChemComp-NA: ![]() ChemComp-EDO: ![]() ChemComp-HOH: |
Source |
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![]() | CELL CYCLE / BROMODOMAIN-CONTAINING PROTEIN 4 ISOFORM LONG / BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 / CAP / HUNK1 / MCAP / MITOTIC CHROMOSOME ASSOCIATED PROTEIN |