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Structure paper

TitleStructural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
Journal, issue, pagesJ Immunother Cancer, Vol. 10, Year 2022
Publish dateAug 2, 2021 (structure data deposition date)
AuthorsSimister, P.C. / Border, E.C. / Vieira, J.F. / Pumphrey, N.J.
External linksJ Immunother Cancer / PubMed:35851311
MethodsX-ray diffraction
Resolution1.54 - 2.27 Å
Structure data

PDB-7pbc:
Crystal structure of engineered TCR (796) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

PDB-7pdw:
Crystal structure of parent TCR (728) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-7pdx:
Crystal structure of parent MAGE-A10 TCR (728)
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-7qpj:
Crystal structure of engineered TCR (756) complexed to HLA-A*02:01 presenting MAGE-A10 9-mer peptide
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T-cell receptor / human leukocyte antigen / immunoglobulin fold / complex / MAGE-A10

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