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TitleNovel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 621, Page 157-161, Year 2022
Publish dateJun 8, 2022 (structure data deposition date)
AuthorsToyota, A. / Goto, M. / Miyamoto, M. / Nagashima, Y. / Iwasaki, S. / Komatsu, T. / Momose, T. / Yoshida, K. / Tsukada, T. / Matsufuji, T. ...Toyota, A. / Goto, M. / Miyamoto, M. / Nagashima, Y. / Iwasaki, S. / Komatsu, T. / Momose, T. / Yoshida, K. / Tsukada, T. / Matsufuji, T. / Ohno, A. / Suzuki, M. / Ubukata, O. / Kaneta, Y.
External linksBiochem. Biophys. Res. Commun. / PubMed:35839742
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-7y1g:
Crystal structure of human PRKACA complexed with DS01080522
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-I5G:
1-chloranyl-~{N}-[(~{S})-(3-chloranyl-4-cyano-phenyl)-[(2~{R},4~{S})-4-oxidanylpyrrolidin-2-yl]methyl]-7-methoxy-isoquinoline-6-carboxamide

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE/THREONINE PROTEIN KINASE / protein kinase inhibitor

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