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-Structure paper
Title | Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 9662-9677, Year 2022 |
Publish date | Jun 7, 2022 (structure data deposition date) |
![]() | Eno, M.S. / Brubaker, J.D. / Campbell, J.E. / De Savi, C. / Guzi, T.J. / Williams, B.D. / Wilson, D. / Wilson, K. / Brooijmans, N. / Kim, J. ...Eno, M.S. / Brubaker, J.D. / Campbell, J.E. / De Savi, C. / Guzi, T.J. / Williams, B.D. / Wilson, D. / Wilson, K. / Brooijmans, N. / Kim, J. / Ozen, A. / Perola, E. / Hsieh, J. / Brown, V. / Fetalvero, K. / Garner, A. / Zhang, Z. / Stevison, F. / Woessner, R. / Singh, J. / Timsit, Y. / Kinkema, C. / Medendorp, C. / Lee, C. / Albayya, F. / Zalutskaya, A. / Schalm, S. / Dineen, T.A. |
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Methods | X-ray diffraction |
Resolution | 2.17 - 2.4 Å |
Structure data | ![]() PDB-8d73: ![]() PDB-8d76: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-QCR: ![]() ChemComp-HOH: ![]() ChemComp-QFO: |
Source |
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![]() | SIGNALING PROTEIN / Protein Kinase / inhibitor / kinase domain / mutation |