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-Structure paper
Title | Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 9678-9690, Year 2022 |
Publish date | Apr 1, 2022 (structure data deposition date) |
![]() | Ketcham, J.M. / Haling, J. / Khare, S. / Bowcut, V. / Briere, D.M. / Burns, A.C. / Gunn, R.J. / Ivetac, A. / Kuehler, J. / Kulyk, S. ...Ketcham, J.M. / Haling, J. / Khare, S. / Bowcut, V. / Briere, D.M. / Burns, A.C. / Gunn, R.J. / Ivetac, A. / Kuehler, J. / Kulyk, S. / Laguer, J. / Lawson, J.D. / Moya, K. / Nguyen, N. / Rahbaek, L. / Saechao, B. / Smith, C.R. / Sudhakar, N. / Thomas, N.C. / Vegar, L. / Vanderpool, D. / Wang, X. / Yan, L. / Olson, P. / Christensen, J.G. / Marx, M.A. |
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Methods | X-ray diffraction |
Resolution | 2.29 - 2.5 Å |
Structure data | ![]() PDB-7ukr: ![]() PDB-7uks: |
Chemicals | ![]() ChemComp-NKF: ![]() ChemComp-HOH: ![]() ChemComp-NL0: |
Source |
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![]() | SIGNALING PROTEIN/INHIBITOR / SOS1 / KRAS / RAS / protein-protein interaction / SIGNALING PROTEIN / SIGNALING PROTEIN-INHIBITOR complex |