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Structure paper

TitleStructures of LIG1 that engage with mutagenic mismatches inserted by pol beta in base excision repair.
Journal, issue, pagesNat Commun, Vol. 13, Page 3860-3860, Year 2022
Publish dateNov 17, 2021 (structure data deposition date)
AuthorsTang, Q. / Gulkis, M. / McKenna, R. / Caglayan, M.
External linksNat Commun / PubMed:35790757
MethodsX-ray diffraction
Resolution2.8 - 3 Å
Structure data

PDB-7sum:
Crystal structure of human ligase I with nick duplexes containing cognate A:T
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-7sx5:
Crystal structure of ligase I with nick duplexes containing mismatch A:C
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-7sxe:
Crystal structure of ligase I with nick duplexes containing cognate G:T
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsLIGASE/DNA / LIGASE-DNA complex / LIGASE / Protein-DNA complex

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