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-Structure paper
Title | Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine. |
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Journal, issue, pages | Nucleic Acids Res., Vol. 50, Page 7669-7679, Year 2022 |
Publish date | Feb 24, 2022 (structure data deposition date) |
Authors | Syroegin, E.A. / Aleksandrova, E.V. / Polikanov, Y.S. |
External links | Nucleic Acids Res. / PubMed:35766409 |
Methods | X-ray diffraction |
Resolution | 2.55 Å |
Structure data | PDB-7u2h: PDB-7u2i: PDB-7u2j: |
Chemicals | ChemComp-MG: ChemComp-K: ChemComp-ZN: ChemComp-SF4: ChemComp-HOH: ChemComp-CLM: |
Source |
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Keywords | RIBOSOME / Chloramphenicol; antibiotic; glycine; non-hydrolyzable; aminoacyl-tRNA; peptidyl-tRNA; 70S ribosome; X-ray structure; pre-attack state; transpeptidation; peptidyl transferase center; context-specificity of drug action; inhibition of translation; uncompetitive inhibitor |