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TitleStructural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.
Journal, issue, pagesNat Commun, Vol. 13, Page 3669-3669, Year 2022
Publish dateSep 15, 2021 (structure data deposition date)
AuthorsPrew, M.S. / Camara, C.M. / Botzanowski, T. / Moroco, J.A. / Bloch, N.B. / Levy, H.R. / Seo, H.S. / Dhe-Paganon, S. / Bird, G.H. / Herce, H.D. ...Prew, M.S. / Camara, C.M. / Botzanowski, T. / Moroco, J.A. / Bloch, N.B. / Levy, H.R. / Seo, H.S. / Dhe-Paganon, S. / Bird, G.H. / Herce, H.D. / Gygi, M.A. / Escudero, S. / Wales, T.E. / Engen, J.R. / Walensky, L.D.
External linksNat Commun / PubMed:35760926
MethodsX-ray diffraction
Resolution1.34 Å
Structure data

PDB-7s7g:
Crystal Structure Analysis of Human VLCAD
Method: X-RAY DIFFRACTION / Resolution: 1.34 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / dehydrogenase / mitochondrial acyl-CoA dehydrogenases / Flavin adenine dinucleotide / deficiency / fatty acid oxidation

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