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Structure paper

TitleCrystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct.
Journal, issue, pagesJ. Virol., Vol. 96, Page e0041822-e0041822, Year 2022
Publish dateAug 4, 2021 (structure data deposition date)
AuthorsJia, H. / Zhong, Y. / Peng, C. / Gong, P.
External linksJ. Virol. / PubMed:35758665
MethodsX-ray diffraction
Resolution1.38 - 2.06 Å
Structure data

PDB-7fjt:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM)
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-7v1b:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH)
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-7v1c:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SIN)
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7v1d:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and GpppA)
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-7v1e:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and m7GpppAmG)
Method: X-RAY DIFFRACTION / Resolution: 1.59 Å

PDB-7v1f:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and GTP)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7v1g:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (with a GMP-Arg28 adduct and in complex with SAM)
Method: X-RAY DIFFRACTION / Resolution: 1.38 Å

PDB-7v1h:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAM and m7GTP)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7v1i:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (with an m7GMP-Arg28 adduct and in complex with SAH)
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-7v1j:
Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and m7GpppA)
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-SAM:
S-ADENOSYLMETHIONINE

ChemComp-CIT:
CITRIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-SFG:
SINEFUNGIN

ChemComp-G3A:
GUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE

ChemComp-V9G:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-(2'-O-METHYL)-ADENOSINE

ChemComp-5GP:
GUANOSINE-5'-MONOPHOSPHATE

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-MGP:
7-METHYL-GUANOSINE-5'-TRIPHOSPHATE

ChemComp-G7M:
N7-METHYL-GUANOSINE-5'-MONOPHOSPHATE

ChemComp-GTA:
P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE

Source
  • omsk hemorrhagic fever virus
KeywordsTRANSFERASE / Guanylyltransferase / methyltransferase / VIRAL PROTEIN

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