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Title3,5,7-Substituted Pyrazolo[4,3- d ]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 8881-8896, Year 2022
Publish dateDec 13, 2021 (structure data deposition date)
AuthorsJorda, R. / Havlicek, L. / Perina, M. / Vojackova, V. / Pospisil, T. / Djukic, S. / Skerlova, J. / Gruz, J. / Renesova, N. / Klener, P. ...Jorda, R. / Havlicek, L. / Perina, M. / Vojackova, V. / Pospisil, T. / Djukic, S. / Skerlova, J. / Gruz, J. / Renesova, N. / Klener, P. / Rezacova, P. / Strnad, M. / Krystof, V.
External linksJ. Med. Chem. / PubMed:35749742
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-7qhl:
Crystal structure of Cyclin-dependent kinase 2/cyclin A in complex with 3,5,7-Substituted pyrazolo[4,3-d]pyrimidine inhibitor 24
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-D5P:
5-(2-amino-1-ethyl)thio-3-cyclobutyl-7-[4-(pyrazol-1-yl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidine

ChemComp-GOL:
GLYCEROL

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-SGM:
MONOTHIOGLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / cyclin-dependent kinase / inhibitor / pyrazolo[4 / 3-d]pyrimidine

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