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Structure paper

TitleStructural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Journal, issue, pagesStructure, Vol. 30, Page 1340-, Year 2022
Publish dateOct 25, 2021 (structure data deposition date)
AuthorsPutta, S. / Alvarez, L. / Ludtke, S. / Sehr, P. / Muller, G.A. / Fernandez, S.M. / Tripathi, S. / Lewis, J. / Gibson, T.J. / Chemes, L.B. / Rubin, S.M.
External linksStructure / PubMed:35716663
MethodsX-ray diffraction
Resolution2.15 - 3 Å
Structure data

PDB-7smc:
p107 pocket domain complexed with ARID4A peptide
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7smd:
p107 pocket domain complexed with EID1 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-7sme:
p107 pocket domain complexed with HDAC1 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

PDB-7smf:
p107 pocket domain complexed with mutated HDAC1-3X peptide
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / Transcription / cyclin box pocket transcriptional regulator

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