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TitleCrystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding.
Journal, issue, pagesJ. Biol. Chem., Vol. 298, Page 102100-102100, Year 2022
Publish dateJan 5, 2022 (structure data deposition date)
AuthorsAsa, M. / Morita, D. / Kuroha, J. / Mizutani, T. / Mori, N. / Mikami, B. / Sugita, M.
External linksJ. Biol. Chem. / PubMed:35667438
MethodsX-ray diffraction
Resolution1.28 - 2.09507668635 Å
Structure data

PDB-7wj2:
Crystal structure of HLA-C*1402 complexed with 8-mer HIV gag peptide
Method: X-RAY DIFFRACTION / Resolution: 1.28 Å

PDB-7wj3:
Crystal structure of HLA-C*1402 complexed with 4-mer lipopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.5634361884 Å

PDB-7wt3:
Crystal structure of HLA-A*2402 complexed with 4-mer lipopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.88765498464 Å

PDB-7wt4:
Crystal structure of HLA-A*2402 complexed with 8-mer Influenza PB1 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.89459140677 Å

PDB-7wt5:
Crystal structure of HLA-A*2450 complexed with 8-mer model peptide
Method: X-RAY DIFFRACTION / Resolution: 2.09507668635 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NA:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-MYR:
MYRISTIC ACID

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
  • synthetic construct (others)
  • influenza a virus
KeywordsIMMUNE SYSTEM / MHC class I / antigen presentation

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