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Structure paper

TitleInsights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 8380-8400, Year 2022
Publish dateNov 29, 2021 (structure data deposition date)
AuthorsLiosi, M.E. / Ippolito, J.A. / Henry, S.P. / Krimmer, S.G. / Newton, A.S. / Cutrona, K.J. / Olivarez, R.A. / Mohanty, J. / Schlessinger, J. / Jorgensen, W.L.
External linksJ. Med. Chem. / PubMed:35653642
MethodsX-ray diffraction
Resolution1.90646266564 - 2.04 Å
Structure data

PDB-7szw:
JAK2 JH2 in complex with JAK249
Method: X-RAY DIFFRACTION / Resolution: 1.90646266564 Å

PDB-7t0p:
JAK2 JH2 IN COMPLEX WITH JAK315
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

Chemicals


ChemComp, No image

ChemComp-DVY:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-E3W:
4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / PSEUDOKINASE DOMAIN / INHIBITOR / COMPLEX / TRANSFERASE / TRANSFERASE-INHIBITOR COMPLEX / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX / SIGNALING PROTEIN

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