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Title | Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 7799-7817, Year 2022 |
Publish date | Jan 17, 2022 (structure data deposition date) |
![]() | Kurz, C.G. / Preuss, F. / Tjaden, A. / Cusack, M. / Amrhein, J.A. / Chatterjee, D. / Mathea, S. / Berger, L.M. / Berger, B.T. / Kramer, A. ...Kurz, C.G. / Preuss, F. / Tjaden, A. / Cusack, M. / Amrhein, J.A. / Chatterjee, D. / Mathea, S. / Berger, L.M. / Berger, B.T. / Kramer, A. / Weller, M. / Weiss, T. / Muller, S. / Knapp, S. / Hanke, T. |
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Methods | X-ray diffraction |
Resolution | 2.4 - 2.6 Å |
Structure data | ![]() PDB-7que: ![]() PDB-7quf: |
Chemicals | ![]() ChemComp-F7I: ![]() ChemComp-HOH: ![]() ChemComp-F8I: |
Source |
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![]() | TRANSFERASE / Kinase Small-molecule binder Inhibitor macrocycle / Kinase Inhibitor Small-molecule binder Macrocycle |