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TitleFirst Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Journal, issue, pagesChembiochem, Vol. 23, Page e202200180-e202200180, Year 2022
Publish dateMar 1, 2022 (structure data deposition date)
AuthorsHerp, D. / Ridinger, J. / Robaa, D. / Shinsky, S.A. / Schmidtkunz, K. / Yesiloglu, T.Z. / Bayer, T. / Steimbach, R.R. / Herbst-Gervasoni, C.J. / Merz, A. ...Herp, D. / Ridinger, J. / Robaa, D. / Shinsky, S.A. / Schmidtkunz, K. / Yesiloglu, T.Z. / Bayer, T. / Steimbach, R.R. / Herbst-Gervasoni, C.J. / Merz, A. / Romier, C. / Sehr, P. / Gunkel, N. / Miller, A.K. / Christianson, D.W. / Oehme, I. / Sippl, W. / Jung, M.
External linksChembiochem / PubMed:35608330
MethodsX-ray diffraction
Resolution2.18 Å
Structure data

PDB-7u59:
Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Piperidine-4-hydroxamic acid Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-LDI:
1-[2-(benzylamino)ethyl]-N-hydroxypiperidine-4-carboxamide

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • danio rerio (zebrafish)
KeywordsHYDROLASE / Histone Deacetylase

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