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Title | Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 7833-7842, Year 2022 |
Publish date | Sep 1, 2021 (structure data deposition date) |
![]() | Ouyang, Y. / Si, H. / Zhu, C. / Zhong, L. / Ma, H. / Li, Z. / Xiong, H. / Liu, T. / Liu, Z. / Zhang, Z. ...Ouyang, Y. / Si, H. / Zhu, C. / Zhong, L. / Ma, H. / Li, Z. / Xiong, H. / Liu, T. / Liu, Z. / Zhang, Z. / Zhang, Z.M. / Cai, Q. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.54001480108 Å |
Structure data | ![]() PDB-7vbt: |
Chemicals | ![]() ChemComp-5ZH: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / RIOK2 |