タイトル | Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. |
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ジャーナル・号・ページ | Int J Mol Sci, Vol. 23, Year 2022 |
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掲載日 | 2021年12月28日 (構造データの登録日) |
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著者 | Honda, A. / Kamata, S. / Akahane, M. / Machida, Y. / Uchii, K. / Shiiyama, Y. / Habu, Y. / Miyawaki, S. / Kaneko, C. / Oyama, T. / Ishii, I. |
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リンク | Int J Mol Sci / PubMed:35563117 |
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手法 | X線回折 |
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解像度 | 1.813 - 2.53 Å |
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構造データ | PDB-7wgl: X-ray structure of human PPAR delta ligand binding domain-bezafibrate co-crystals obtained by co-crystallization 手法: X-RAY DIFFRACTION / 解像度: 2.091 Å PDB-7wgn: X-ray structure of human PPAR delta ligand binding domain-pemafibrate co-crystals obtained by co-crystallization 手法: X-RAY DIFFRACTION / 解像度: 1.813 Å PDB-7wgo: X-ray structure of human PPAR gamma ligand binding domain-bezafibrate co-rystals obtained by co-crystallization 手法: X-RAY DIFFRACTION / 解像度: 2.36 Å PDB-7wgp: X-ray structure of human PPAR gamma ligand binding domain-fenofibric acid co-crystals obtained by co-crystallization 手法: X-RAY DIFFRACTION / 解像度: 2.53 Å PDB-7wgq: X-ray structure of human PPAR gamma ligand binding domain-pemafibrate co-crystals obtained by co-crystallization 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å |
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化合物 | ChemComp-P7F: (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid / K-877 / アゴニスト*YM
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由来 | homo sapiens (ヒト)
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キーワード | TRANSCRIPTION / Nuclear receptor / Protein-ligand complex / PPAR |
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