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Title | An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron. |
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Journal, issue, pages | Nat Microbiol, Vol. 7, Page 716-725, Year 2022 |
Publish date | Jul 8, 2021 (structure data deposition date) |
Authors | Quan, B.X. / Shuai, H. / Xia, A.J. / Hou, Y. / Zeng, R. / Liu, X.L. / Lin, G.F. / Qiao, J.X. / Li, W.P. / Wang, F.L. ...Quan, B.X. / Shuai, H. / Xia, A.J. / Hou, Y. / Zeng, R. / Liu, X.L. / Lin, G.F. / Qiao, J.X. / Li, W.P. / Wang, F.L. / Wang, K. / Zhou, R.J. / Yuen, T.T. / Chen, M.X. / Yoon, C. / Wu, M. / Zhang, S.Y. / Huang, C. / Wang, Y.F. / Yang, W. / Tian, C. / Li, W.M. / Wei, Y.Q. / Yuen, K.Y. / Chan, J.F. / Lei, J. / Chu, H. / Yang, S. |
External links | Nat Microbiol / PubMed:35477751 |
Methods | X-ray diffraction |
Resolution | 2.1 Å |
Structure data | PDB-7fay: PDB-7faz: |
Chemicals | ChemComp-2XI: ChemComp-HOH: ChemComp-2RI: ChemComp-NA: |
Source |
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Keywords | VIRAL PROTEIN / coronavirus / protease / inhibitor / complex / VIRAL PROTEIN. / complex. |