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Structure paper

TitleStructural and functional insight into mismatch extension by human DNA polymerase alpha.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 119, Page e2111744119-e2111744119, Year 2022
Publish dateMay 29, 2021 (structure data deposition date)
AuthorsBaranovskiy, A.G. / Babayeva, N.D. / Lisova, A.E. / Morstadt, L.M. / Tahirov, T.H.
External linksProc. Natl. Acad. Sci. USA / PubMed:35467978
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-7n2m:
Crystal structure of DNA polymerase alpha catalytic core in complex with dCTP and template/primer having T-C mismatch at the post-insertion site
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA/RNA / DNA replication / DNA polymerase / T-C mismatch / RNA primer / DNA template / human protein / DNA polymerase alpha / TRANSFERASE-DNA-RNA complex

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