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-Structure paper
Title | Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants. |
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Journal, issue, pages | J. Biol. Chem., Vol. 298, Page 101972-101972, Year 2022 |
Publish date | Jan 18, 2022 (structure data deposition date) |
Authors | Greasley, S.E. / Noell, S. / Plotnikova, O. / Ferre, R. / Liu, W. / Bolanos, B. / Fennell, K. / Nicki, J. / Craig, T. / Zhu, Y. ...Greasley, S.E. / Noell, S. / Plotnikova, O. / Ferre, R. / Liu, W. / Bolanos, B. / Fennell, K. / Nicki, J. / Craig, T. / Zhu, Y. / Stewart, A.E. / Steppan, C.M. |
External links | J. Biol. Chem. / PubMed:35461811 |
Methods | X-ray diffraction |
Resolution | 1.63 - 2.088 Å |
Structure data | PDB-7tll: PDB-7u28: PDB-7u29: |
Chemicals | ChemComp-4WI: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Protease / SARS-CoV-2 / covalent complex / inhibitor / HYDROLASE-INHIBITOR complex / mutant / Omicron / P132H / nirmatrelvir / PF-07321332 / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |