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-Structure paper
Title | Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 13, Page 665-673, Year 2022 |
Publish date | Nov 19, 2021 (structure data deposition date) |
![]() | May-Dracka, T.L. / Gao, F. / Hopkins, B.T. / Hronowski, X. / Chen, T. / Chodaparambil, J.V. / Metrick, C.M. / Cullivan, M. / Enyedy, I. / Kaliszczak, M. ...May-Dracka, T.L. / Gao, F. / Hopkins, B.T. / Hronowski, X. / Chen, T. / Chodaparambil, J.V. / Metrick, C.M. / Cullivan, M. / Enyedy, I. / Kaliszczak, M. / Kankel, M.W. / Marx, I. / Michell-Robinson, M.A. / Murugan, P. / Kumar, P.R. / Rooney, M. / Schuman, E. / Sen, A. / Wang, T. / Ye, T. / Peterson, E.A. |
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Methods | X-ray diffraction |
Resolution | 2.9 Å |
Structure data | ![]() PDB-7svp: |
Chemicals | ![]() ChemComp-CI0: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / phosphodiesterase / HKD motif / HYDROLASE-HYDROLASE INHIBITOR complex |