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-Structure paper
Title | Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 6287-6312, Year 2022 |
Publish date | Mar 11, 2022 (structure data deposition date) |
![]() | Teuscher, K.B. / Meyers, K.M. / Wei, Q. / Mills, J.J. / Tian, J. / Alvarado, J. / Sai, J. / Van Meveren, M. / South, T.M. / Rietz, T.A. ...Teuscher, K.B. / Meyers, K.M. / Wei, Q. / Mills, J.J. / Tian, J. / Alvarado, J. / Sai, J. / Van Meveren, M. / South, T.M. / Rietz, T.A. / Zhao, B. / Moore, W.J. / Stott, G.M. / Tansey, W.P. / Lee, T. / Fesik, S.W. |
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Methods | X-ray diffraction |
Resolution | 1.808 - 1.9 Å |
Structure data | ![]() PDB-7u9y: ![]() PDB-7uas: |
Chemicals | ![]() ChemComp-BEN: ![]() ChemComp-M4U: ![]() ChemComp-HOH: ![]() ChemComp-MBU: |
Source |
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![]() | Transcription/Transcription Inhibitor / Transcription-Transcription Inhibitor complex / WDR5 / structure-based design |