タイトル | Identification of Novel GSK-3 beta Hits Using Competitive Biophysical Assays. |
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ジャーナル・号・ページ | Int J Mol Sci, Vol. 23, Year 2022 |
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掲載日 | 2022年2月25日 (構造データの登録日) |
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著者 | Balboni, B. / Tripathi, S.K. / Veronesi, M. / Russo, D. / Penna, I. / Giabbai, B. / Bandiera, T. / Storici, P. / Girotto, S. / Cavalli, A. |
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リンク | Int J Mol Sci / PubMed:35409221 |
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手法 | X線回折 |
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解像度 | 2.21 - 2.75 Å |
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構造データ | PDB-7u2z: Crystal structure of human GSK3B in complex with G12 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å PDB-7u31: Crystal structure of human GSK3B in complex with G5 手法: X-RAY DIFFRACTION / 解像度: 2.38 Å PDB-7u33: Crystal structure of human GSK3B in complex with ARN9133 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7u36: Crystal structure of human GSK3B in complex with ARN1484 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å |
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化合物 | ChemComp-L7C: (3R)-1-[3-(2-fluorophenyl)propanoyl]-N-(pyridin-2-yl)pyrrolidine-3-carboxamide
ChemComp-L7I: 5-(4-fluorophenyl)-4-[1-(methanesulfonyl)azetidin-3-yl]pyrimidin-2-amine
ChemComp-L7R: 3-[2-amino-5-(4-fluorophenyl)pyrimidin-4-yl]-N,N-dimethylazetidine-1-sulfonamide
ChemComp-L7W: (3S)-1-[(2-fluorophenoxy)acetyl]-N-(pyridin-2-yl)pyrrolidine-3-carboxamide
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE/TRANSFERASE Inhibitor / Inhibitor / Complex / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex |
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