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TitleCrystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP + /NADPH and the substrate folic acid.
Journal, issue, pagesActa Crystallogr. ,Sect. F, Vol. 78, Page 170-176, Year 2022
Publish dateOct 8, 2021 (structure data deposition date)
AuthorsDello Iacono, L. / Di Pisa, F. / Mangani, S.
External linksActa Crystallogr. ,Sect. F / PubMed:35400669
MethodsX-ray diffraction
Resolution1.81 Å
Structure data

PDB-7pxx:
The crystal structure of Leishmania major Pteridine Reductase 1 in complex with substrate folic acid
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

Chemicals

ChemComp-FOL:
FOLIC ACID

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • leishmania major (eukaryote)
KeywordsOXIDOREDUCTASE / Enzyme-Substrate complex / Rossmann fold / cofactor

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