+Search query
-Structure paper
Title | Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 68, Page 128718-128718, Year 2022 |
Publish date | Feb 20, 2021 (structure data deposition date) |
![]() | Gero, T.W. / Heppner, D.E. / Beyett, T.S. / To, C. / Azevedo, S.C. / Jang, J. / Bunnell, T. / Feru, F. / Li, Z. / Shin, B.H. ...Gero, T.W. / Heppner, D.E. / Beyett, T.S. / To, C. / Azevedo, S.C. / Jang, J. / Bunnell, T. / Feru, F. / Li, Z. / Shin, B.H. / Soroko, K.M. / Gokhale, P.C. / Gray, N.S. / Janne, P.A. / Eck, M.J. / Scott, D.A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.3 Å |
Structure data | ![]() PDB-7ltx: |
Chemicals | ![]() ChemComp-ANP: ![]() ChemComp-MG: ![]() ChemComp-YFA: ![]() ChemComp-HOH: |
Source |
|
![]() | TRANSFERASE/Inhibitor / EGFR / kinase / allosteric / inhibitor / quinazolinone / TRANSFERASE / TRANSFERASE-Inhibitor complex |