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TitleDirected Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.
Journal, issue, pagesAcs Chem. Biol., Vol. 17, Page 969-986, Year 2022
Publish dateOct 26, 2020 (structure data deposition date)
AuthorsDurvanger, Z. / Boros, E. / Nagy, Z.A. / Hegedus, R. / Megyeri, M. / Dobo, J. / Gal, P. / Schlosser, G. / Angyan, A.F. / Gaspari, Z. ...Durvanger, Z. / Boros, E. / Nagy, Z.A. / Hegedus, R. / Megyeri, M. / Dobo, J. / Gal, P. / Schlosser, G. / Angyan, A.F. / Gaspari, Z. / Perczel, A. / Harmat, V. / Mezo, G. / Menyhard, D.K. / Pal, G.
External linksAcs Chem. Biol. / PubMed:35378038
MethodsX-ray diffraction
Resolution2.42 Å
Structure data

PDB-7arx:
Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1
Method: X-RAY DIFFRACTION / Resolution: 2.42 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • helianthus annuus (common sunflower)
KeywordsIMMUNE SYSTEM / protease / inhibitor / complex

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